| 摘要: |
| 目的：探讨多巴胺联合卡托普利在肺炎合并心力衰竭患儿中的应用价值。方法：选取2016-2018年湖北省随州市中心医院住院治疗的肺炎合并心力衰竭患儿92例，按随机数表法分为对照组和研究组各46例。对照组患儿给予常规治疗，研究组患儿给予多巴胺联合卡托普利治疗，观察两组患儿临床症状体征、心肌酶水平改善情况，评价疗效及用药安全性。结果：与对照组相比，研究组治疗后心率（HR）、呼吸频率（RR）、乳酸脱氢酶（LDH）、天门冬氨酸氨基转移酶（AST）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）均降低，而血氧饱和度（SaO2）升高；研究组住院时间、HR及RR恢复正常时间、听诊肺部啰音及喘促消失时间均短于对照组（P均<0.05）。两组患儿不良反应发生率比较差异无统计学意义。结论：多巴胺联合卡托普利可显著缓解小儿肺炎合并心力衰竭的临床症状体征，改善心肌酶水平，缩短住院时间，且用药安全性较高。 |
| 关键词: 儿童 肺炎合并心力衰竭 多巴胺 卡托普利 临床结局 |
| DOI：doi:10.13407/j.cnki.jpp.1672.108X.2021.08.007 |
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| 基金项目: |
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| Dopamine Combined with Captopril in the Treatment of Children with Pneumonia Complicated with Heart Failure |
| Wei Wei1, Huang Airong2 |
| (1. Hubei Suizhou Central Hospital, Hubei Suizhou 441300, China; 2. Suizhou Hospital of Traditional Chinese Medicine, Hubei Suizhou 441300, China) |
| Abstract: |
| Objective: To probe into the application value of dopamine combined with captopril in the treatment of children with pneumonia complicated with heart failure. Methods: A total of 92 children with pneumonia complicated with heart failure admitted into Hubei Suizhou Central Hospital from 2016 to 2018 were extracted to be divided into the control group and the study group via the random number table, with 46 cases in each group. The control group was given conventional treatment, while the study group received dopamine combined with captopril. The clinical symptoms and signs, the improvement of myocardial enzyme levels in two groups were observed, and the clinical efficacy and drug safety were evaluated. Results: Compared with the control group, the heart rate (HR), respiratory rate (RR), lactate dehydrogenase (LDH), aspartate transaminase (AST), creatine kinase (CK) and creatine kinase isoenzyme (CK-MB) decreased in the study group after treatment, while the blood oxygen saturation (SaO2) increased. The length of stay, the recovery time of HR and RR, the disappearance time of lung rales and wheezing in the study group were shorter than those in the control group (P<0.05). There was no statistically significant difference in the incidence of adverse drug reactions between two groups. Conclusion: Dopamine combined with captopril can significantly alleviate the clinical symptoms and signs of children with pneumonia complicated with heart failure, improve the myocardial enzyme levels and shorten the length of stay with higher safety. |
| Key words: children pneumonia complicated with heart failure dopamine captopril clinical outcome |
