| 摘要: |
| 目的:探讨1 例临床药师参与治疗的急性髓系白血病(AML)儿童侵袭性镰刀菌病的经验。方法:总结1 例AML 诱导化
疗后接受伏立康唑预防但仍发生镰刀菌侵袭感染的1 例患儿诊疗过程,从临床药师角度分析多学科协作的个体化用药精准治
疗及不良反应管理。结果:临床药师提供的药学监护服务使患儿感染控制效果良好,避免了严重不良事件的发生。结论:镰刀
菌侵袭性感染治疗需基于药物可及性、儿童药代动力学特征及治疗药物监测(TDM) 制定联合抗真菌方案,在免疫功能低下患
儿中实施多学科协作对优化方案提高疗效与降低不良反应至关重要。 |
| 关键词: 儿童 侵袭性镰刀菌病 两性霉素B 胆固醇硫酸酯复合物 泊沙康唑 治疗药物监测 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.07.008 |
|
| 基金项目:广东省医学科学技术研究基金项目,编号202311139951533。 |
|
| Diagnosis and Treatment of Fusarium Infection Secondary to Chemotherapy in a Child with Acute MyeloidLeukemia |
| Wen Jianyun, Li Xiu, Chen Juan, Pei Fuyu |
| ((Nanfang Hospital, Southern Medical University, Guangzhou 510515, China)) |
| Abstract: |
| Objective: To probe into the experience of treatment for a child with acute myeloid leukemia (AML) complicated with
invasive fusariosis by clinical pharmacists. Methods: The treatment process of a child who developed invasive infection caused by
Fusarium despite receiving voriconazole prophylaxis after AML induction chemotherapy was summarized. Results: Analysis of
multidisciplinary collaborative individualized medication and adverse drug reaction management was performed from the perspective of
clinical pharmacists. The pharmaceutical care provided by clinical pharmacists achieved good infection control effect and avoided the
occurrence of severe adverse events. Conclusion: Treatment of invasive fusariosis requires a combination antifungal regimen based on
drug accessibility, pediatric pharmacokinetics characteristics and therapeutic drug monitoring (TDM), multidisciplinary collaboration in
immunocompromised children is essential to improve the efficacy and reduce adverse drug reactions. |
| Key words: children invasive fusariosis amphotericin B cholesteryl sulfate complex posaconazole therapeutic drug monitoring |
