| 摘要: |
| 目的:探讨产前硫酸镁(MgSO4 )暴露对<32 周早产儿动脉导管未闭(PDA)的影响。方法:回顾性分析2020 年6 月1 日
至2024 年6 月30 日青岛大学附属医院儿童医学中心新生儿科收治的胎龄<32 周早产儿资料,按照产前孕母有无应用MgSO4
分为暴露组与对照组。采用单因素及多因素logistic 回归分析产前MgSO4 暴露对有血流动力学意义的PDA(hsPDA 及相关次要
结局的影响。进一步将早产儿按照出生胎龄分为<28 周亚组和28~32 周亚组,比较产前MgSO4 暴露对不同胎龄早产儿PDA 的
影响。结果:本研究共纳入<32 周的早产儿216 例,其中暴露组173 例,对照组43 例。暴露组与对照组hsPDA 发生率比较差异
无统计学意义(P>0. 05)。暴露组生后3~7 天PDA 发生率高于对照组(P<0. 05)。暴露组有创呼吸机辅助通气、Ⅲ~Ⅳ级脑室
内出血、脑白质病变及住院期间病死率低于对照组(P<0. 05)。单因素及多因素logistic 回归分析显示,产前MgSO4 暴露早产儿
生后3~7 天PDA 发生率增加(P<0. 05)。分层分析发现,产前MgSO4 暴露对胎龄28~32 周早产儿生后3~7 天PDA 发生率影
响更显著(P<0. 05)。结论:产前MgSO4 应用未增加胎龄<32 周早产儿hsPDA 发生率。 |
| 关键词: 动脉导管未闭 硫酸镁 早产儿 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2025.10.007 |
|
| 基金项目:青岛市西海岸新区科技惠民专项,编号2022-54 |
|
| Effects of Prenatal Magnesium Sulfate Exposure on Patent Ductus Arteriosus and Related Complications inPreterm Infants <32 weeks |
| Wang He1, Liu Yan1, Sun Mengya1, Wang Lijun1, Jiang Hong1, Li Xianghong1 |
| ((Children’s Medical Center, the Affiliated
Hospital of Qingdao University, Shandong Qingdao 266003, China)) |
| Abstract: |
| Objective: To probe into the effects of prenatal magnesium sulfate (MgSO4 ) exposure on patent ductus arteriosus (PDA) in
preterm infants <32 weeks. Methods: Retrospective analysis was performed on preterm infants with gestational age <32 weeks admitted
into the Neonatology Department of Children’s Medical Center, the Affiliated Hospital of Qingdao University from Jun. 1st , 2020 to Jun.
30th , 2024. These infants were divided into the exposure group and control group based on the application of prenatal MgSO4 . Univariate
and multivariate logistic regression analysis were performed to assess the effect of prenatal MgSO4 on hemodynamically significant patent
ductus arteriosus (hsPDA) and related secondary outcomes. The preterm infants were further divided into <28 weeks subgroup and 28 to
32 weeks subgroup according to gestational age at birth, and the effects of prenatal MgSO4 exposure on PDA in preterm infants of
different gestational ages were compared. Results: Totally 216 preterm infants <32 weeks were enrolled, with 173 cases in the exposure
group and 43 cases in the control group. There was no statistically significant difference in the incidence of hsPDA between exposure
group and control group (P>0. 05). The incidence of PDA at the 3 to 7 d after birth in exposure group was higher than that in control
group (P < 0. 05). The incidence of invasive mechanical ventilation, grade Ⅲ to Ⅳ intraventricular hemorrhage, periventricular
leukomalacia and mortality during hospitalization in the exposure group was lower than that in the control group (P<0. 05). Univariate
and multivariate logistic regression analysis showed that prenatal MgSO4 exposure increased the incidence of PDA at the 3 to 7 d after
birth (P<0. 05). The effect of prenatal MgSO4 exposure was more significant in preterm infants with gestational age of 28 to 32 weeks (P<
0.05). Conclusion: Prenatal MgSO4 exposure does not increase the incidence of hsPDA in preterm infants with gestational age <32 weeks. |
| Key words: patent ductus arteriosus magnesium sulfate preterm infants |
