| 摘要: |
| 目的:探讨桑菊膏对肺炎患儿 C 反应蛋白(CRP)和降钙素原(PCT)水平的影响,并模拟评价其疗效。 方法:选取我院 2023 年 6 月-2024 年 6 月收治的肺炎喘嗽(风热闭肺证)患儿。 按治疗方案分为常规组(n = 40)和联合组(n = 40),经倾向性评 分匹配(PSM)法匹配后各 25 例。 重复方差分析 CRP、PCT 水平、中医症候积分。 双重差分(DID)模型评估疗效。 非线性混合 效应模型模拟药效时间-效应关系,Bootstrap 法验证模型稳健性。 结果:联合组 CRP、PCT 水平、中医证候积分低于常规组,体征 改善时间缩短。 联合组总有效率更高。 药效呈时间依赖性累积。 基线中医症状积分与 Emax 存在剂量效应关系:Emax,i = 9. 86+ 1. 84×(Baseline-6. 09)。 模型适配度及预测效能良好。 结论:在常规治疗基础上联合桑菊膏可显著降低儿童肺炎 CRP、PCT 水平。 |
| 关键词: 桑菊膏 风热闭肺证 肺炎 模型化评价 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2026.09.010 |
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| 基金项目: |
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| Efficacy and Time-Effect Model of Sangju Decoction in the Adjuvant Treatment of Children with Pneumonia of Wind-Heat Syndrome |
| Wang Yuxiang |
| (Bozhou Hospital of Traditional Chinese Medicine, Anhui Bozhou 236800, China) |
| Abstract: |
| Objective: To investigate the effects of Sangju decoction on levels of C-reactive protein (CRP) and procalcitonin (PCT) in children with pneumonia, and to simulate and evaluate the efficacy. Methods: Children with pneumonia and asthma ( wind-heat syndrome) admitted into our hospital from Jun. 2023 to Jun. 2024 were extracted to be divided into the conventional group (40 cases) and combined group (40 cases) based on treatment intention. After propensity score matching (PSM), 25 cases were selected for each group. Repeated measures analysis of variance was used to analyze CRP and PCT levels, and traditional Chinese medicine syndrome scores. The difference-in-differences (DID) model was used to evaluate the efficacy. A nonlinear mixed-effects model was used to simulate the time-effect correlation of drug efficacy, and the Bootstrap method was used to verify the robustness of the model. Results: The levels of CRP and PCT, and traditional Chinese medicine syndrome scores in combined group were lower than those in conventional group, and the improvement time of clinical signs was shortened. The total effective rate of combined group was higher. The drug efficacy showed a time-dependent cumulative effect. There was a dose-effect correlation between the baseline traditional Chinese medicine syndrome scores and Emax: Emax,i = 9. 86+1. 84×(Baseline-6. 09). The model fitness and predictive performance were good. Conclusion: Sangju decoction combined with conventional treatment can reduce the levels of CRP and PCT in children with pneumonia, showing significant clinical effects. |
| Key words: Sangju decoction wind-heat syndrome pneumonia model-based evaluation |
