| 摘要: |
| 目的:探讨基于新生儿血清脂质运载蛋白2(LCN2)、前蛋白转化酶枯草溶菌素9(PCSK9)水平建立预测急性呼吸窘迫综
合征(ARDS)预后模型及防治策略。方法:选取2022 年1 月-2024 年1 月我院收治的112 例早产导致的ARDS 新生儿为ARDS
组,根据氧合指数(OI)将ARDS 新生儿划分为3 类:ARDS 轻度组42 例、中度组41 例和重度组29 例。另选取同阶段在本院分
娩的健康新生儿60 例作为对照组。使用酶联免疫吸附试验(ELISA)检测各组新生儿血清中LCN2 和PCSK9 水平。Pearson 法
分析ARDS 新生儿血清中LCN2 和PCSK9 水平之间的相关性。Logistic 回归分析血清LCN2、PCSK9 对新生儿中重度ARDS 发生
的影响。受试者工作特征(ROC)曲线分析血清LCN2、PCSK9 在新生儿ARDS 诊断及病情评估中的价值。结果:ARDS 组新生
儿血清LCN2、PCSK9 水平均明显高于对照组(P<0. 05);且与ARDS 轻度组比较,中度和重度组血清LCN2、PCSK9 水平升高
(P<0. 05)。Pearson 分析显示,ARDS 组新生儿血清LCN2、PCSK9 水平呈正相关(P<0. 05)。Logistic 回归分析显示,血清LCN2、
PCSK9 是中重度ARDS 新生儿的独立危险因素( P<0. 05)。ROC 曲线分析表明,LCN2、PCSK9 联合检测诊断ARDS 新生儿的
AUC 高于LCN2、PCSK9 单独检测(P<0. 05);且联合检测诊断中重度ARDS 新生儿的AUC 也高于LCN2、PCSK9 单独检测(P<
0. 05)。结论:LCN2、PCSK9 在ARDS 新生儿血清中表达水平均升高,二者联合检测对ARDS 新生儿诊断和病情评估的价值较高。 |
| 关键词: 急性呼吸窘迫综合征 新生儿 脂质运载蛋白2 前蛋白转化酶枯草溶菌素9 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2026.11.010 |
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| 基金项目:基金项目:秦皇岛市重点研发计划科技支撑项目,编号202301A246。 |
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| Expression Levels of Serum Lipocalin-2 and Proprotein Convertase Subtilisin / Kexin Type 9 in NeonatalAcute Respiratory Distress Syndrome and Assessment for Severity of Disease and Prevention and TreatmentStrategies |
| Li Shuangquan, Jiang Chenxi, Zhu Hongbin |
| (Maternal and Child Health Care Hospital of Qinhuangdao, Hebei Qinhuangdao
066300, China) |
| Abstract: |
| Objective: To explore the establishment of prognostic model and prevention strategies for predicting acute respiratory distress
syndrome based on neonatal serum lipocalin-2 (LCN2) and proprotein convertase subtilisin/ kexin type 9 (PCSK9). Methods: Totally
112 neonates with ARDS admitted into our hospital from Jan. 2022 to Jan. 2024 were extracted as the ARDS group. According to the
oxygenation index (OI), neonates with ARDS were divided into three categories: mild ARDS group (42 cases), moderate ARDS group
(41 cases), and severe ARDS group (29 cases). Another 60 healthy neonates delivered in our hospital at the same stage were selected
as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the levels of LCN2 and PCSK9. Pearson method
was used to analyze the correlation between LCN2 and PCSK9 levels. Logistic regression equation was used to analyze the effects of
serum LCN2 and PCSK9 on the occurrence of moderate to severe ARDS in neonates. Receiver operating characteristic (ROC) curve was
used to analyze the value of serum LCN2 and PCSK9 in the diagnosis and disease condition assessment of neonates with ARDS. Results:
The levels of LCN2 and PCSK9 in ARDS group were greatly higher than those in control group (P<0. 05). Compared with mild ARDS group, the levels of LCN2 and PCSK9 increased in moderate group and severe ARDS group (P <0. 05). Pearson analysis showed a
positive correlation between levels of LCN2 and PCSK9 in neonates with ARDS (P<0. 05). Logistic regression analysis showed that serum
LCN2 and PCSK9 were independent risk factors for neonates with moderate to severe ARDS (P<0. 05). ROC curve showed that the AUC
of combined detection of LCN2 and PCSK9 for diagnosing ARDS in neonates was higher than that of LCN2 and PCSK9 detected separately
(P<0. 05). The AUC of combined detection for diagnosing moderate to severe ARDS in neonates was also higher than that of LCN2 and
PCSK9 detected separately (P<0. 05). Conclusion: The expression levels of LCN2 and PCSK9 are both elevated in the serum of neonates
with ARDS, and the combined detection has high value in the diagnosis and disease condition assessment of neonates with ARDS. |
| Key words: acute respiratory distress syndrome neonates lipocalin-2 proprotein convertase subtilisin/ kexin type 9 |
