| 摘要: |
| 目的:观察细菌溶解产物OM-85BV对学龄前期儿童哮喘发作及其鼻部症状的疗效。方法:选取1~5岁轻中度哮喘慢性持续期患儿150例,采用Excel生成的随机数表分为试验组100例和对照组50例,所有患儿均接受丙酸氟替卡松吸入气雾剂吸入治疗(每次200 μg,bid),其中试验组在丙酸氟替卡松吸入气雾剂吸入治疗基础上口服OM﹣85BV 3.5 mg/d,每月连用10 d,连续使用3个月为1个疗程,间隔3个月重复第2个疗程。治疗第3、6、9、12个月时进行随访,为期1年。结果:试验组患儿在治疗第12个月时喘息发作次数和在治疗第6个月起急性呼吸道感染(ARTI)的发作次数较对照组少,差异有统计学意义(P<0.05)。试验组各项鼻部症状在观察期内均有明显改善(P<0.05)。结论:OM﹣85BV 能有效减少缓解期患儿哮喘急性发作的次数、改善其鼻塞和流涕症状以及儿童ARTI次数。 |
| 关键词: 细菌溶解产物 哮喘 过敏性鼻炎 急性呼吸道感染 |
| DOI：doi:10.13407/j.cnki.jpp.1672-108X.2017.01.003 |
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| 基金项目:2014中国医师协会呼吸免疫专项课题 |
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| Bacterial Lysates OM-85BV in Children with Asthma and Nasal Allergy Symptoms |
| Li Jingyang, Bao Jun, Bao Yixiao |
| (Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China) |
| Abstract: |
| Objective: To observe the effect of bacterial lysates OM-85BV to asthmatic attacks and nasal symptoms in asthma children. Methods: One hundred and fifty children with moderate asthma in chmnic persistent period who were aged from 1 to 5 years old were selected, children were divided into the treatment group and control group. The control group was given fluticasone propionate inhalation (200 μg, bid). On this basis, the treatment group was given OM﹣85BV 3.5 mg every day for 10 days each month, 3 months as a course, and the interval of the two courses should be 3 months. Children were followed for 12 months by visiting every three months. Results: (1) The frequency of wheezing treatment after 12 months and the frequency of ARTIs treatment after 6 months in treatment group were less than those in control group. There were significant differences between two groups (P<0.05). (2) The nasal symptoms in treatment group were improved obviously compared with the control group after treatments (P<0.05). Conclusion: Administration of OM-85BV can significantly reduced the frequency of wheezing and ARTIs in asthmatic children. It also can release the patients' nasal symptoms and reduce the frequency of ARTIs. |
| Key words: bacterial lysates asthma allergic rhinitis acute respiratory infection |
