| 摘要: |
| 目的:观察蛋白琥珀酸铁治疗小儿缺铁性贫血的临床疗效。方法:选取120 例缺铁性贫血患儿,随机分为观察组和对照
组各60 例,对照组给予硫酸亚铁治疗,观察组给予蛋白琥珀酸铁治疗,比较两组患儿的血液学指标、微量元素、铁代谢、临床疗
效、不良反应和随访6 个月内的复发情况。结果:治疗后,两组患儿红细胞、血红蛋白、锌、铜、钙、血清铁蛋白和血清铁水平均明
显升高(P<0.01),镉、血清转铁蛋白和总铁结合力水平均明显降低(P<0.01)。观察组治疗后临床总有效率为96. 67%,高于对
照组的85.00%,差异有统计学意义(χ2=4.904,P<0.05)。治疗期间两组不良反应发生率比较差异有统计学意义(χ2=0.439,
P<0.01)。治疗后及疗程结束随访期间观察组复发例数明显少于对照组(χ2=3.927,P<0.05)。结论:蛋白琥珀酸铁治疗小儿缺
铁性贫血疗效显著,临床应用价值较高。 |
| 关键词: 蛋白琥珀酸铁 缺铁性贫血 小儿 |
| DOI：10.13407/j.cnki.jpp.1672-108X.2017-05-008 |
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| 基金项目: |
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| Iron Protein Succinylate in Treatment of Children with Iron Deficiency Anemia |
| He Jin'e, Gao Chunyan, Shi Donglin |
| (Yan'an University Affiliate Hospital) |
| Abstract: |
| Objective: To study the clinical efficacy of iron protein succinylate in treatment of children with iron deficiency anemia.
Methods: One hundred and twenty cases of children with iron deficiency anemia were randomly divided into two groups: sixty children
in the observation group who were given iron protein succinylate and 60 children in the control group who were treated with ferrous
sulfate. The indexes of hematology, trace elements, iron metabolism, efficacy, adverse reactions and recurrence within 6 months were
collected and analyzed. Results: After treatment, red blood cell (RBC), hemoglobin (Hb), zinc, copper, calcium, serum ferritin
(SF), serum iron (SI) were increased significantly (P<0. 01), cadmium, transferrin (TF) and total iron binding capacity (TRBF)
were decreased significantly in two groups (P<0.01). Compared with control group, the total effective rate had increased (96.67% vs
85.00%, P<0.05), the cases of adverse reactions and recurrence had decreased in the observation group (P<0.01 or P<0.05).
Conclusion: Iron protein succinylate shows more accurate clinical efficacy in treatment of children with iron deficiency anemia. It is
worthy of clinical application. |
| Key words: iron protein succinylate iron deficiency anemia child |
